predictive values of tnf-α, il-6, il-10 for radiation pneumonitis
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abstract
background: to investigate the expression of tnf-α, il-6, il-10 in the plasma of patients with lung cancer who received radiation therapy (rt), and to analyze the correlation between these cytokines and radiation pneumonitis (rp). materials and methods: patients with lung cancer who received 3d-crt in our hospital were prospectively evaluated. circulating cytokine levels were measured with elisa before rt and at the end of rt. regular follow-up was undertaken 3 months after rt. statistical analysis was applied to determine the relevance of cytokines to radiation-induced lung injury. results: of 104 patients, 29 (27.9%) developed rp. the levels of tnf-α and il-6 levels in the plasma after rt were significantly higher than before rt (p<0.05), whereas il -10 levels were significantly lower after rt than before rt (p<0.05). before rt, tnf-α levels were higher in rp group (p<0.05),but there were no differences in tnf-α levels after rt. no association was observed between il-6 and il-10 levels and the risk of rp. univariate analysis showed that baseline pulmonary function, smoking history, histopathology, lung volume receiving ≥20 gy (v20), mean lung dose (mld) and total radiation dose were related to rp, but only mld was an independent risk factor for rp in lung cancer patients (or>1). conclusion: tnf-α levels in plasma were closely related to rp but still cannot be used as predictors for rp.
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Journal title:
iranian journal of radiation researchجلد ۱۴، شماره ۳، صفحات ۱۷۳-۱۷۹
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